Knowledge, preventive behaviors and risk perception of students of Kashan University of Medical Sciences towards COVID-19

Background: Students are a very important part of young society whose awareness affects the health of family and friends. At the same time as the COVID-19 pandemic, the present study was conducted to investigate the level of Knowledge, Preventive Behaviors and Risk Perception of students of Kashan University of Medical Sciences towards COVID-19. Methods: This cross-sectional study was conducted in 2022. In total, 330 students from Kashan University of Medical Sciences were selected via random sampling method. Data collection tools were a questionnaire including 4 sections of demographic information, awareness (15 questions) and preventive behaviors (9 questions) and risk perception (2 questions). The Mann-Whitney and Kruskal-Wallis tests were used for data analysis. Findings: The knowledge of students of Kashan University of Medical Sciences about the ways of transmission, origin, symptoms, incubation period, treatment, how to diagnose, the importance of using a mask and hand hygiene has been between 60 to 98% and very good. The students' preventive behaviors towards all the mentioned items were between 65 and 95% and were very good. About half of the university students had a high risk of COVID-19. Conclusion: Due to the high prevalence of this virus and the lack of absolutely effective medicine in the treatment of this disease, it is necessary to raise the level of awareness of students with appropriate training, so that we can see an increase in preventive behaviors and understanding of risk among students.

World Assumptions and Coping Related to Trauma as Predictors of General Mental Health and Acute Stress Symptoms Among Iranian Muslims During the COVID-19 Outbreak

The COVID-19 outbreak is a new potentially traumatic event that may have some unknown effects on mental health. The aim of this study was to examine how two theoretical frameworks related to coping with trauma, including shattered assumptions and coping with trauma, could explain mental health and acute stress symptoms among the general population during the COVID-19 outbreak. The participants included 212 Iranian Muslims who filled out the online survey. Women and people with non-fixed jobs reported more mental health deterioration and acute stress symptoms. There were no significant differences between people with or without COVID-19 in terms of mental health symptoms, experiencing acute stress symptoms, and world assumptions. Results showed that world assumption and forward-focused coping could predict mental health symptoms and acute stress symptoms beyond COVID-19 specific stress. Assumptions related to the meaningfulness of the world and trauma-focused coping were associated with a higher score in general mental health symptoms and acute stress, but assumptions related to the benevolence of the world, self-worth, and forward-focused coping were associated with lower mental health and acute stress symptoms. This could suggest that world assumptions could buffer or endanger mental health during crises such as the pandemic. In addition, it seems that forward-focus coping is effective for managing new life challenges during the COVID-19 outbreak. In contrast, the more people address the negative and catastrophic effects of COVID-19 (such as trauma-focused coping), the more they are prone to developing mental health symptoms. This study showed that among Iranian Muslims, some world assumptions (for example, the meaningfulness of world) and some kinds of coping (for example, trauma-focused coping) were not as protective factor as in non-Muslim countries.

Indirect Effects of COVID-19 Pandemic on Children?s Ocular Health (Myopia and Digital Eye Strain): A Narrative Review

Background: The outbreak of COVID-19 has significantly affected people's lives worldwide. Governments have used various measures to contain the spread of the pandemic, including confinement policies that have changed children's lifestyles. Children had to limit their outdoor activities and daily routine to indoor activities. Alternative learning systems, such as online and offline teaching via digital devices have replaced traditional teaching methods. Therefore, children have to spend many hours in front of digital devices. As a natural side effect of the pandemic, these changes may influence children's ocular health who may not be able to complain about these problems as early as adults.Objectives: This study reviews the literature regarding the effects of the COVID-19 pandemic on children's eye health, including myopia and digital eye strain.Methods: For this narrative review, a comprehensive literature search was performed on December 30, 2021, in Google Scholar, PubMed, and Scopus using the following keywords: "COVID-19," "lockdowns," "children," "ocular health," "eye health," "visual health," "ocular complications," "myopia," " myopia progression," "digital eye strain," "computer vision syndrome," "quarantine," and "prevention." A total of 22 eligible studies were identified for review.Results: Studies performed during the COVID-19 pandemic have shown an increase in myopia prevalence, incidence, and progression in children, especially among young children. Strategies imposed by governments to control the spread of COVID-19 during confinement have led to dramatic changes in children's lifestyles. These measures have compelled children to restrict outdoor activities and increase their near-work time (e.g., online e-learning), which contributes to the increase in digital eye strain and myopia progression.Conclusions: Children's eye health can be influenced by the COVID-19 outbreak. These can serve as a warning to policymakers, health professionals, teachers, parents, and children about the effects of pandemics, such as COVID-19, on children's visual health and the need to implement preventive and therapeutic measures.

Coating of favipiravir (FVP) on silver nanoparticles: First principle study

Silver nanoparticles, thanks to their antiviral and antibacterial properties, have great potential in a variety of applications, such as drug-delivery carriers. The coating properties of silver nanoparticles (size range of 1.6 nm) with a well-known drug, Favipirair, were investigated in this study using quantum mechanical and classical atomistic molecular dynamics simulation in order to use as the drug delivery to treat COVID-19 disease. The drug molecule's optimized structure, frequencies, charge distribution, and electrostatic potential maps were simulated using density functional theory (DFT) at the B3LYP/6–311++g(d,p) level of theory. The coating of AgNP with each of these drugs was then studied using molecular dynamics simulation. The interaction affinity obtained from MD results agrees with the DFT results on drug adsorption on the Ag(1 1 1) slab. © 2023

Temperature and COVID-19 Incidence: An Ecologic Study

Background: According to the hypothesis, COVID-19 is less prevalent in regions with warm climates. Contradictory results have led us to investigate the correlation between temperature and the cumulative COVID-19 incidence rate. Methods: We obtained COVID-19 data from CRONALAB, COVID-DASHBOARD, and MCMC databases of Fars Province, Iran, linked the data and finalized daily COVID-19 cases. The daily data on the temperature was gotten from meteorological stations' reports from March 21, 2020, to March 21, 2021, for each county of Fars Province, Southern Iran. The daily weighted cumulative incidence rate of COVID-19 cases was calculated for all counties, separately. Initially, for uniform data visualization, the average air temperature data were transformed into ranked percentiles. Then, to visually assess the study hypothesis, the distribution of COVID-19 cumulative incidence was visualized on percentiles of temperature. Given the non-linear distribution of the data, we performed exploratory analyses using the generalized additive models and locally weighted (polynomial) regressions to choose the best response function. Then, the generalized linear models were used to parametrically build the model. Results: The generalized additive models showed a small decreasing, near horizontal, linear pattern for COVID-19 incidence rate as the function of temperature (pseudo R2: 0.001, deviance explained: 0.13%, coefficient:-0.02). The GLMs showed head-to-head results (deviance explained: 0.13%, coefficient:-0.02], supported by similar Akaike information criteria (AICs) (34945). However, according to the locally weighted regressions model's curve, lower COVID-19 incidence rates were recorded on days when the temperatures ranged from 60 to 80 percentiles, equal to 20°C to 25°C in a cold climate and 25°C to 35°C in a warm climate. This is while the rates increased at lower and upper temperatures. Conclusion: Daily COVID-19 incidence rate cannot be explained as a function of daily temperature in Southern parts of Iran. Higher rates of disease transmission out of the range of 20°C to 25°C for cold temperatures and 25°C to 35°C for warm climates might be linked to people's indoor gatherings, coupled with insufficient ventilation. © 2023, Gonabad University of Medical Sciences. All rights reserved.

The consequences of the COVID-19 pandemic on marketing performance considering the role of technology (Case study: Iranian chain hotels)

The extant paper aims to explore the effects of the COVID-19 pandemic on marketing activities. In this respect, the study adopted Structural Equation Modeling (SEM) using SPSS26 and Smart PLS-3 to analyze the descriptive survey that was distributed among 200 hotel managers. The findings revealed that although the pandemic affected the technology application in the hospitality sector positively, it also has negative impacts on marketing performance. The results also illustrated the considerable effect of technology on marketing performance. Thus, by providing a comprehensive research model, the study calls on hotel managers and executives to reconsider their marketing activities. © 2023 The Author(s)

Gamified Customer Experience and Engagement in Amazon Online Retailing Company in The Covid -19 era

This study aims to fill the gap between gamification features and their impacts on practical marketing activities in The Covid -19 era by providing a comprehensive analysis between gamification features: immersion (storytelling), achievement (reward), and social (competition) on customer experience (CX) and engagement (CE). In this study, a Quasi-experimental design method was used to examine the relationship of the gamification features on CX and engagement. To investigate, an online survey was distributed to 200 students and they were exposed to three different scenarios randomly. Structural equation modeling, Analysis of variance (ANOVA), t-test, regression, path analysis and Sobel test were used to evaluate the impacts of gamification on CX and engagement. The results reveal that gamification has positive effect on CE and CX while, achievement has a more substantial impact than immersion and social on CX, competition has a stronger positive effect than storytelling but weaker positive effect than reward. © 2023 Academy of Taiwan Information Systems Research. All rights reserved.

Therapeutic Efficacy of Melatonin in Patients with Coronavirus 2019: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The efficacy of melatonin in the treatment of patients with coronavirus 2019 (COVID-19) is controversial. This review has summarized the evidence on the efficacy of oral melatonin compared to placebo in patients with mild to moderate COVID-19 infection. We searched four international online databases and all randomized clinical trials (RCTs) that investigated the effects of melatonin compared with the placebo on clinical outcomes, including mortality, discharge time, O2 saturation (SaO2), and c-reactive protein (CRP) levels in patients with COVID-19 infection, were included. The standard random-effects model with hybrid continuity correction was used to pool the risk ratio (RR), weighted mean difference (WMD), and the I2 index to assess the heterogeneity. A total of 272 patients from five RCTs were included. Our meta-analysis showed melatonin compared to placebo, decreased discharge time (WMD=-0.93 days;95% confidence interval [CI]:-2.94 to 1.07, P=0.36;I2=56.78%) and the risk of mortality (RR=0.72;95% CI:0.25 to 2.13, P=0.56;I2=0.0%) in COVID-19 patients. Melatonin intake compared to placebo significantly increased SaO2 (WMD=1.38%;95% CI:0.09 to 2.68, P=0.04;I2=49.82%) and decreased the CRP levels (WMD=-7.24 mg/l;95% CI:-11.28 to-3.21, P<0.001) in a sensitivity analysis. Our findings showed the efficacy of melatonin compared to placebo in patients with mild to moderate COVID-19 infection. [GMJ.2022;11:e2562] DOI:10.31661/gmj.v11i.2562

Rehabilitation Educators′ Perceptions of Clinical Education Challenges in Iran: Is COVID-19 Having Redundant Effects?

Background: Clinical education is a core component of the curriculum of undergraduate rehabilitation students. Nevertheless, this field more than any other field of education has many shortcomings that should be addressed. Methods: The aim of this study was to explore the challenges of clinical education from the perspective of rehabilitation educators with particular focus on the new challenges created bythe COVID-19 outbreak. This qualitative study was conducted through purposeful sampling. Semi-structured interviews were conducted with 12 rehabilitation clinical educators of Ahvaz Jundishapur University of Medical Sciences, Iran. Data analysis was accomplished according to conventional content analysis. To prove the trustworthiness of the data, credibility, dependability, confirmability, and transferability were assessed. Results: Through data analysis, 240 initial codes were extracted in three main categories and nine sub-categories, indicating redundant challenges imposed by COVID-19 comprising restricted clinical resources (inadequate patient number and diversity, inadequate equipment, limited clinical space, inadequate manpower), an inefficient clinical education system (poor management of clinical education programs, insufficient clinical evaluation), and personal and professional characteristics of the students (lack of students' practical knowledge, lack of motivation, fear). Conclusion: The results of this study provide deeper insight into the perceptions and experiences of rehabilitation educators regarding clinical education challenges. At present, an accidental and unexpected problematic event (COVID-19 pandemic) has inflicted detrimental effects on various aspects of clinical rehabilitation sciences. It is necessary to implement changes in future plans which include adaptations for COVID-19. 2022© The Authors. Published by JRSR. All rights reserved.

Comparison of clinical, radiological and laboratory findings in discharged and dead patients with COVID-19

Background: Coronavirus disease 19 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Iran was the first country where the SARS-Cov-2 was detected in the Middle East. In the current study, we aimed to evaluate the clinical, radiological and laboratory findings in hospitalized COVID-19 confirmed cases in Iran. Methods: The clinical manifestations, radiological data, laboratory findings, and the underlying diseases of the patients with COVID-19 were obtained from electronic medical records. Next, this information was compared in discharged and dead patients. Results: Overall, 4028 patients with COVID-19 including 3088 discharged, 778 dead, and 162 still hospitalized patients were enrolled in this study. The highest percentage of people who recovered (55%) was between 30 and 60 years old and the highest percentage of deaths (74.4%) was more than 60 years old. Based on demographic data, 50.05% were female and 49.95% were male. Clinical evaluations revealed that dyspnea (56.9%), cough (31.4%) and fever (17.8%) were the most manifestations. Comorbidities were significantly higher in the dead group. Laboratory analysis revealed abnormalities in lymphocyte count (LYM), erythrocyte sedimentation rate (ESR), and inflammatory biomarkers such as C-reactive protein (CRP). The most prevalent computed tomography (CT) scan data were ground-glass opacity (GGO) (30.5%) and consolidation (9.4%). Conclusions: Laboratory parameters and clinical and radiological findings help to evaluate the follow-up of the disease in patients. Age and comorbidities are factors that predispose people to COVID-19. Further research is needed to evaluate the effects of various factors on the progression of COVID-19 infection.

The vulnerability of technology-based business during COVID-19: an indicator-based conceptual framework

Purpose COVID-19 has affected most business activities, including technology-based business. The higher the business vulnerability rating, the greater the impacts. After identifying three dimensions of vulnerability (exposure, business sensitivity and response capacity), this study aims to determine the potential components and indicators of the vulnerability of technology-based businesses. Design/methodology/approach Using the indicator approach, a comprehensive vulnerability model was developed for assessing the vulnerability of the technology-based business against COVID-19. Findings In this study, COVID-19, as a biological threat and an exogenous shock, was considered the exposure dimension. Business characteristics, job characteristics, business owner-manager demographics, product and supplier characteristics were identified as the sensitivity dimension, while resources, human capital, technological capitals, social capitals, institutional capitals, infrastructures, management capacity and supply chain capabilities were defined as the adaptive business capability or response capacity. To determine vulnerability and response capacity against exogenous shocks and a pandemic crisis, the framework can act as a useful checklist for managers and owners of technology-based businesses. Originality/value Research on the COVID-19, especially in the technology-based business, is still at the emergent stage. This study is a pioneering effort to review the literature on business vulnerability and provide a framework to reduce business vulnerability using the indicator-based approach.

An Analytical Model for Confronting the Omicron Variant During COVID-19 Pandemic: A System Dynamic Approach

The global outbreak of COVID-19 began in December 2019 in Wuhan, China, and affected the entire world in a short time. Over time, the emergence of new species of the disease, the pace of response to it has also strongly affected, and with the emergence of the newest species called Omicron. Knowing and reviewing the system and publishing publications in the community is essential for sound policies. It is necessary to investigate the spread of COVID-19 to make proper policies. System dynamic can be adopted as an approach to the behavior evaluation of the COVID-19 pandemic. The present study introduces a system dynamic model to explore the effects of different factors on the pandemic and therapeutic and non-therapeutic modalities. Vaccination is evaluated as the main approach to prevent the disease. The influential factors of pandemic prevention and control are examined based on the SEIR model and policies such as vaccination. The safest way to prevent this epidemic is vaccination. Therefore, a policy that benefits the entire population and will be necessary is producing and purchasing vaccines. From 19 July 2021, the rate of vaccine imports to Iran has increased significantly, and therefore it is predicted that by the end of 2022, Iran's general vaccination will end, after which the number of cases and mortality rates will decline. Vaccines are the ultimate solution to contagious diseases to control disease spread and provide safety to deal with the infection. The results suggested that the fatality rate of the susceptible population was reduced by vaccination and protective protocols. Thus, this paper aims to analyze factors influencing the spread of COVID-19 and prevent the disease. © 2022 Materials and Energy Research Center. All rights reserved.

Factors Related to Nurses and Physicians’ Knowledge and Attitudes Towards Palliative Care

Background: Changes in the course of diseases, their treatment, and care provision result in the need for a specific type of care known as palliative care. Medical staff’s knowledge and awareness of palliative care is important in this regard. Objectives: This study aims to examine the caregivers’ knowledge and awareness of palliative care and to determine the related predictors. Methods: In this cross-sectional study, 277 subjects were selected from among the caregivers working in the selected teaching hospitals in Iran through non-randomized sampling method. The subjects were asked to fill the online questionnaire which consisted of 3 sections including demographic data, knowledge, and attitude toward palliative care. Descriptive, inferential statistics, correlation and regression analyses were performed. Results: The mean scores of care providers’ attitude and knowledge were 140.90 ± 11.56 and 19.36 ± 2.73 respectively. There was a significant relationships between some variables such as working place, education level, age, palliative care-related working expe-rience, and the necessity to pass training courses and the mean scores of attitude and knowledge. Conclusions: Since palliative care providers’ level of knowledge and attitude were reported to be moderate, training courses at different levels in the form of clinical courses should be offered with the aim of improving care providers’ skills and scientific abilities. It is essential to include the related topics in the curricula of academic programs.

Application of the Extended Planned Behavior Theory to Predict COVID-19 Preventive Behaviors

Aims: Preventive behaviors play an important role in reducing mortality caused by this disease. This study aimed to determine the application of the extended theory of planned behavior to predicting preventive behaviors against COVID-19. Instrument & Methods: In this descriptive-analytical cross-sectional study, 416 university students were selected and examined through virtual networks through convenience and snowball sampling methods. The data collection tool was developed by the researcher-made questionnaire based on the extended theory of planned behavior. Data were analyzed using descriptive statistics and correlation test and linear regression by SPSS 18 software. Findings: A positive and significant correlation was observed between the mean of all the studied theoretical constructs with preventive behaviors against COVID-19 (p<0.01). Attitudes, subjective norms, perceived behavioral control, and perception of others' behavior predicted 43% of behavioral intention variance. Moreover, behavioral intention perceived behavioral control and perception of others’ behavior predicted 56% of preventive behaviors variance against COVID-19. Behavioral intention, attitude, perception of others' behavior, subjective norms, and perceived behavioral control had the greatest impact on COVID-19 preventive behaviors. Conclusion: The extended theory of planned behavior can be used as an appropriate framework in designing educational interventions to promote preventive behaviors against COVID-19. © 2022, Tarbiat Modares University. All rights reserved.

A Review of Environmental Factors for the Spread of Coronavirus and the Role of Expert Healthcare Workers in Prevention

Background: Coronavirus has a high transmissibility, and there are various ways to transmit it. Health forces must consider all possible routes of transmission. Therefore, the present study aimed to investigate the role of environmental factors in the spread of coronavirus. Methods: This study was a systematic review. The articles were first selected according to the title related to the research objectives;then the of the study articles and related articles were separated. Finally, after a thorough review of the articles, research related to the objectives of this study was selected. A total of 245 review sources were selected, and finally 63 sources were entered the study. Findings: The coronavirus can be transmitted in different ways. Inanimate surfaces, water and sewage, air, and contaminated hands are important in this regard. The corona virus may remain in the contaminated water of the carrier for days to weeks. The highest concentration of corona virus was in the room air of infected patients. The coronavirus stays in the water contaminated with the corona carrier for a long time, and may be transmitted to other people. Conclusion: Proper ventilation, disinfection of public places, observance of social distance, attention to water and waste hygiene, and personal hygiene should be considered to prevent the spread of coronavirus. Attention to prevention is the main concern of healthcare workers, and more attention should be paid to the role of them as the main lever in prevention. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.

A systematic review of AR/VR in operations and supply chain management: maturity, current trends and future directions

Purpose This research aims to provide systematic insight into the current maturity of augmented reality (AR) and virtual reality (VR) in operations and supply chain management (OSCM), by analyzing the existing literature, contemporary concepts, data and gaps for future research directions. Design/methodology/approach This research uses information from existing literature regarding timeline trends, publishers, research design and method, industry engagement, geographic location, active authors and affiliated universities, concentrated topics, theories and maturity in its review. A collection of publishing databases from 1997 to 2021 were explored using the keywords "Augmented Reality," "Virtual Reality" and "Operations" and/or "Supply Chain" in their title and to examine which publications to be included. Based on the search, a total of 164 journal articles were selected, and information on a chain of variables was collected. Findings There has been a significant publication growth over the past 25 years regarding the adoption of AR/VR in OSCM. Key findings indicate that 52% of the publications were focused on manufacturing, with only 10% of the existing literature using background theories. AR/VR can be observed at the introduction and growth phase and have yet to reach their maturity. Furthermore, there is limited utilization of AR/VR as drivers in facilitating sustainable practices in OSCM by academics and practitioners, albeit a strong promise exists. Finally, the prospective applications of AR/VR toward post-COVID-19 supply chains recovery require special attention. Research limitations/implications This systematic review is limited to considering only academic articles available from Emerald, Elsevier, Taylor and Francis, Springer, Scopus, JSTOR and EBSCO containing the keyword parameters. Originality/value The study used a bibliometric review to identify the trends and maturity in the evolution of AR/VR in OSCM. This research provides a better understanding of current research practices and offers directions toward the adoption of AR/VR in OSCM.

Differential alteration trend of white blood cells (Wbcs) and monocytes count in severe and non-severe covid-19 patients within a 7-day follow-up

Background and Objectives: Several studies have focused on the alterations of hematological parameters for a better un-derstanding of the COVID-19 pathogenesis and also their potential for predicting disease prognosis and severity. Although some evidence has indicated the prognostic values of thrombocytopenia, neutrophilia, and lymphopenia, there are conflicting results concerning the leukocyte and monocyte count. Materials and Methods: In this retrospective Double Centre study, we reviewed the results of WBC and monocyte counts of 1320 COVID-19 patients (243 of whom (18.4%) had severe disease) both on admission and within a 7-day follow-up. Results: We found that both the number of monocytes and the percentage of monocytosis were higher in the severe group;however, it was not statistically significant. On the other hand, we found that not only the mean number of WBCs was significantly higher in the severe cases also leukocytosis was a common finding in this group;indicating that an increased number of WBC may probably predict a poor prognosis. Also, the monocyte count was not affected by age;however, univariate analysis showed that the percentage of leukocytosis was significantly greater in the older group (>50) with an odds ratio of 1.71 (P: 0.003). Conclusion: Alteration of monocytes either on admission or within hospitalization would not provide valuable data about the prediction of COVID-19 prognosis. Although the rapidly evolving nature of COVID-19 is the major limitation of the present study, further investigations in the field of laboratory biomarkers will pave the way to manage patients with severe disease better.

Innovation intelligence and its role in environmental uncertainty management: a conceptual framework

Purpose: Organizations need actionable knowledge to cope with environmental uncertainty, make effective decisions and develop innovation strategies. Since innovation evolves through generations, the present study aims to unravel and define innovation intelligence, considering this transformation, and discuss how environmental uncertainty is resolved in each one. Design/methodology/approach: This article is a conceptual paper that employs a typology and model approach in its research design Findings: Contexts are categorized into ordered and unordered (according to the Cynefin framework), in which intelligence with prediction and control approaches are applied for uncertainty management, respectively. Also, the three generations of innovation management, namely, technology push, market pull and a combination of these two (hybrid), intelligence benefit from a prediction approach, and in the networked (collaborative) generation, intelligence takes advantage of a control approach. Research limitations/implications: The conceptual approach adopted in this research is limited to, and focused on, understanding intelligence, innovation intelligence and presenting preliminary insights into their relationship with uncertainty management. Practical implications: This research guides decision-makers to adopt the appropriate intelligence approach to manage uncertainty during their innovation management process and illustrate it by the industry uncertainty matrix and COVID-19 pandemic situation. Originality/value: This study proposes a typology of intelligence based on different knowledge pyramids. Also, it introduces innovation intelligence and its relation to knowledge management and environmental uncertainty management that has not yet been clearly addressed in the literature. Moreover, it determines the uncertainty management approaches for each variant of innovation intelligence. © 2020, Emerald Publishing Limited.

The efficacy of remdesivir in coronavirus disease 2019 (COVID-19): A systematic review

Background and Objectives: Researchers all around the world are working hard to find an effective treatment for the new coronavirus 2019. We performed a comprehensive systematic review to investigate the latest clinical evidence on the efficacy and safety of treatment with Remdesivir in hospitalized patients with COVID-19. Materials and Methods: We performed a systematic search in Pubmed, Embase, Web of Science, Google scholar and MedRxiv for relevant observational and interventional studies. The outcomes measures were mortality rates, improvement rates, time to clinical improvement, all adverse event rates and severe adverse event rates. Results: Three randomized controlled trials and 2 cohort studies were included in our study. In the 2 cohort studies, patients received Remdesivir for 10 days. 2 RCTs evaluated 10-day efficacy of treatment with Remdesivir versus placebo group and the other RCT compared its 5-day regimen versus 10-day regimen. Visual inspection of the forest plots revealed that the efficacy of Remdesivir was not much different in reducing 28-day mortality versus 14-day mortality rates. Besides, 10-day treatment regimen overpowered 5-day treatment and placebo in decreasing time to clinical improvement. All adverse event rates did not have a significant difference;however, severe adverse event rate was lower in the 5-day Remdesivir group compared to the 10-day and placebo groups. Conclusion: 5-day course of Remdesivir therapy in COVID-19 patients is probably efficacious and safe, and patients with-out invasive mechanical ventilation benefit the most. Treatment can be extended to 10 days if satisfactory improvement is not seen by day 5. Most benefits from Remdesivir therapy take place in the first 14 days of the start of the treatment.